Anti-PTPRA antibody produced in rabbit

PTPRA is a transmembrane phosphatase that regulates cell proliferation, cell adhesion, integrin signaling, and growth factor response. This phosphatase also activates proteins of the Src family. PTPRA inhibits cell growth in breast cancer and contributes to tumorigenesis in colon carcinoma . Anti-PTPRA antibody is specific for human and mouse PTPRA. In immunoblotting, detection of the PTPRA band is specifically inhibited by the immunizing peptide.

Protein tyrosine phosphatase alpha (PTPRA) is a transmembrane phosphatase with a relatively short, highly glycosylated extracellular domain, a transmembrane domain, and a tandem phosphatase domain. The amino-terminal domain predominantly mediates catalytic activity, whereas the carboxyterminal domain serves as a regulatory subunit.

synthetic peptide corresponding to an internal region of human PTPRA, conjugated to KLH. The corresponding sequence is identical in mouse and differs by one amino acid in rat.

Anti-PTPRA antibody is suitable for use in western blot (0.25-0.5 μg/mL using lysates of NIH-3T3 or PC12 cells) and indirect immunofluorescence (5-10 μg/mL using paraformaldehyde fixed HUVEC cells).

Anti-PTPRA antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Protein tyrosine phosphatase alpha (PTPRA) is implicated in several signaling pathways, including insulin receptor signaling, cellular transformation and cell spreading and migration. It regulates cell proliferation, cell adhesion, integrin signaling, and growth factor response. PTPRA inhibits cell growth in breast cancer and contributes to tumorigenesis in colon carcinoma.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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