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SAB4200320

Anti-PTPRF antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-LAR, Anti-Leukocyte antigen-related tyrosine phosphatase, Anti-Tyrosine-protein phosphatase receptor type F

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.44
Human Protein Atlas Number:
HPA012710
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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~139 kDa, antigen ~150 kDa, antigen ~210 kDa

species reactivity

human

technique(s)

western blot: 1:250-1:500 using lysates of HEK-293T cells over-expressing human PTPRF.

UniProt accession no.

P10586

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTPRF(5792)

General description

PTPRF removes phosphate group from β-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function .

Immunogen

synthetic peptide corresponding to an internal region of human PTPRF, conjugated to KLH. The corresponding sequence differs by two amino acids in mouse and rat.

Application

Anti-PTPRF antibody is suitable for use in immunoblot (1:250-1:500 using lysates of HEK-293T cells over-expressing human PTPRF).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M4845

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Mélanie J Chagnon et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 82(6), 664-675 (2005-01-28)
The protein tyrosine phosphatases (PTPs) have emerged as critical players in diverse cellular functions. The focus of this review is the leukocyte common antigen-related (LAR) subfamily of receptor PTPs (RPTPs). This subfamily is composed of three vertebrate homologs, LAR, RPTP-sigma
Robert A Mooney et al.
Current topics in medicinal chemistry, 3(7), 809-819 (2003-04-08)
The leukocyte common antigen-related protein, LAR, is a receptor-like protein tyrosine phosphatase (PTP) which has a wide tissue distribution. Post-translational processing cleaves the proprotein into two non-covalently associated subunits, an extracellular subunit resembling a cell adhesion molecule with three immunoglobulin-like
M Streuli et al.
The EMBO journal, 11(3), 897-907 (1992-03-01)
The human transmembrane molecule LAR is a protein tyrosine phosphatase (PTPase) with a cell adhesion molecule-like extracellular receptor region. The structure of LAR hinted at its involvement in the regulation of tyrosine phosphorylation through cell-cell or cell-matrix interactions. We show
F Ahmad et al.
The Journal of biological chemistry, 272(1), 448-457 (1997-01-03)
The receptor-type protein-tyrosine phosphatase LAR (for leukocyte common antigen-related) has been implicated as a physiological regulator of the insulin receptor. To demonstrate a functional interaction between LAR and the insulin receptor, we incubated CHO cells overexpressing the human insulin receptor

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