Anti-Rheb (C-terminal region) antibody produced in rabbit

Ras homolog enriched in brain (Rheb), a member of the family of Ras small G-proteins, is a cellular immediate early gene in the brain. It has a C-terminal CaaX box.

synthetic peptide corresponding to a sequence at the C-terminal region of human Rheb, conjugated to KLH. The corresponding sequence is identical in rat Rheb and highly conserved (94% sequence identity) in mouse Rheb.

Anti-Rheb (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Ras homolog enriched in brain (Rheb) plays an important role in cell growth, proliferation, apoptosis, autophagy and neuronal axonal regeneration. The effects of Rheb are mediated via the mammalian target of rapamycin (mTOR) protein kinase. Rheb activity in mTor signaling is regulated by a dual mechanism. Rheb appears to activate mTOR complex 1 (mTORC1) via direct binding to mTOR. Rheb is required for mTORC1 signaling and myelination during brain development.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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