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SAB4200417

Anti-XPO4 antibody, Mouse monoclonal

Name: Anti-XPO4 antibody, Mouse monoclonal
Brand: SIGMA

clone XP-12, purified from hybridoma cell culture

Synonym(s):

Anti-Exportin 4, Anti-KIAA1721, Monoclonal Anti-Exp4, Monoclonal Anti-XPO4 antibody produced in mouse

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

XP-12, monoclonal

Application:

IF, WB

Citations:

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biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

XP-12, monoclonal

form

buffered aqueous solution

mol wt

antigen ~130 kDa

species reactivity

bovine, chicken, hamster, monkey, canine, human

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: suitable, western blot: 1.0-2.0 μg/mL using extracts of HeLa cells

isotype

IgG1

UniProt accession no.

Q9C0E2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... XPO4(64328)

General description

Monoclonal Anti-XPO4 (mouse IgG1 isotype) is derived from the hybridoma XP-12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide. Exportin 4 (XPO4) belongs to the karyopherins protein family. It is conserved amongst higher eukaryotes but, lacks obvious orthologues in yeast.

Immunogen

a peptide corresponding to a sequence at the C-terminus of human XPO4.

Application

Monoclonal Anti-XPO4 antibody produced in mouse has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Exportin 4 (XPO4) facilitates the nuclear export of eIF-5A (eukaryotic translation initiation factor 5A). In addition, it also mediates transport Sox proteins, as well as regulates Smad signaling. These functions of XPO4 suggests it to be a candidate tumor suppressor gene. Indeed, its involvement in the progression of human hepatocellular carcinomas (HCC) has been demonstrated, implicating this protein as a potential target for treatment of HCC.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

012M4804

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Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors

Gontan C, et al.

The Journal of Cell Biology, 185, 27-27 (2009)

Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma

Liang XT, et al.

Journal of Gastroenterology and Hepatology, 26, 544-549 (2011)

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes

Lipowsky G, et al.

The Embo Journal, 19, 4362-4371 (2000)

The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran

Kurisaki A, et al.

Molecular and Cellular Biology, 26, 1318-1318 (2006)

Exportin 4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9.

Megumi Tsuchiya et al.

PloS one, 6(10), e25694-e25694 (2011-10-13)

Sox9 is a transcription factor that is required for tissue development in mammals. In general, such transcription factors require co-regulators for precise temporal and spatial control of the activation and inactivation of the numerous genes necessary for precise development during

Global Trade Item Number

SKU	GTIN
SAB4200417-200UL	04061836270698

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