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SAB4200432

Anti-RASD2 antibody produced in rabbit

Name: Anti-RASD2 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-RAS homolog enriched in striatum, Anti-RASD family, member 2, Anti-RHES, Anti-TEM-2

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Citations:

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Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~34 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells overexpressing human RASD2, indirect immunofluorescence: 5-10 μg/mL using HEK-293T cells overexpressing RASD2, western blot: 0.5-1 μg/mL using lysates of HEK-293T cells overexpressing human RASD2

UniProt accession no.

Q96D21

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RASD2(23551)

Description

General description

RASD2 (Ras homolog enriched in striatum) is a member of the family of Ras small G proteins. RASD2 is a 266 amino acid GTP binding protein, which is expressed in the striatum. The gene is located on human chromosome 22 (q12.3).

Immunogen

synthetic peptide corresponding to a sequence near the C-terminus of human RASD2, conjugated to KLH. The corresponding sequence is highly conserved (83% sequence identity) in rat and mouse RASD2.

Application

Anti-RASD2 antibody produced in rabbit has been used in:

immunoblotting
immunofluorescence
immunoprecipitation

Biochem/physiol Actions

RASD2 (Ras homolog enriched in striatum) prevents the activation of G_αs and promotes dopamine D2 receptor-mediated activation of G_αi/o. It mediates mammalian target of rapamycin (mTOR) signaling and L-DOPA(L-3,4-dihydroxyphenylalanine)-induced dyskinesia. It is suggested to be the principal determinant of striatal mTOR activation. RASD2 is associated with Huntington′s disease (HD). Rhes-mHtt interaction is implicated in neuropathology of HD in the striatum.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

052M4765

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Global Trade Item Number

SKU	GTIN
SAB4200432-200UL	04061835647033