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SAB4200440

Anti-COG5 antibody produced in rabbit

Name: Anti-COG5 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-13S Golgi transport complex 90 kDa subunit, Anti-COG complex subunit 5, Anti-Component of oligomeric Golgi complex 5, Anti-Conserved oligomeric Golgi complex subunit 5, Anti-GTC-90, Anti-Golgi transport complex 1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Human Protein Atlas Number:

HPA020300

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~100 kDa

species reactivity

human, rat, mouse

concentration

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using whole extracts of HEK-293T cells overexpressing human COG5.

UniProt accession no.

Q9UP83

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COG5(10466)
mouse ... Cog5(238123)
rat ... Cog5(298945)

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General description

Conserved oligomeric Golgi complex 5 (COG5), also known as CDG2I, GTC90 and GOLTC1, is a member of the conserved oligomeric Golgi (COG) complex. The complex is an evolutionarily conserved multisubunit protein COG complex. COG is composed of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.

Immunogen

peptide corresponding to the C-terminal region of human COG5, conjugated to KLH. The corresponding sequence is identical in mouse, rat, canine and monkey COG5.

Application

Anti-COG5 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Conserved Oligomeric Golgi complex 5 (COG5) complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. Mutations in COG5 gene result in congenital disorder of glycosylation type 2I.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

052M4783

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Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery

Pokrovskaya ID, et al.

Glycobiology, 21(12), 1554-1569 (2011)

COG5 variants lead to complex early onset retinal degeneration, upregulation of PERK and DNA damage.

Sami Tabbarah et al.

Scientific reports, 10(1), 21269-21269 (2020-12-06)

Leber congenital amaurosis (LCA), a form of autosomal recessive severe early-onset retinal degeneration, is an important cause of childhood blindness. This may be associated with systemic features or not. Here we identified COG5 compound-heterozygous variants in patients affected with a

Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates

Quental R, et al.

BMC Evolutionary Biology, 10(1), 212-212 (2010)

Global Trade Item Number

SKU	GTIN
SAB4200440-200UL	04061838036377

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