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SAB4200449

Anti-SOX11 antibody produced in rabbit

Name: Anti-SOX11 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-SRY (sex determining region Y)-box 11

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About This Item

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Citations:

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells overexpressing human SOX11., indirect immunofluorescence: 5-10 μg/mL using human HeLa cells., western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells overexpressing human tagged-SOX11 (~72 kDa).

UniProt accession no.

P35716

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SOX11(6664)

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General description

Sex determining region Y (SRY)-box 11 (SOX11) protein is a member of the SRY-related high mobility group (HMG)-box (SOX) family of transcription factors. This protein is expressed in adult immature neurons but is normally not expressed in any other adult tissue. SOX11 gene is mapped on the human chromosome at 2p25.2.

Immunogen

peptide corresponding to an internal region of human SOX11, conjugated to KLH. The corresponding sequence is identical in monkey and pig and differs by 3 amino acids in mouse and rat.

Application

Anti-SOX11 antibody produced in rabbit may be used in:

immunoblotting
immunoprecipitation
immunofluorescence

Biochem/physiol Actions

Anti-SOX11 recognizes human SOX11.

Sex determining region Y (SRY)-box 11 (SOX11) is involved in the regulation of tissue remodeling during embryonic development of the central nervous system and the determination of cell fate. This protein plays a role in tumorigenesis. SOX11 protein acts as a biomarker in mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL) and Burkitt lymphomas (BL). Upregulation of the SOX11 gene is associated with ovarian cancer, medulloblastomas, gliomas and brain tumor.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

052M4787V

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Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications.

Maria Carmela Vegliante et al.

PloS one, 6(6), e21382-e21382 (2011-07-09)

Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells

Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.

Xiao Wang et al.

PloS one, 5(11), e14085-e14085 (2010-12-03)

The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet

Sox11 is required to maintain proper levels of Hedgehog signaling during vertebrate ocular morphogenesis.

Lakshmi Pillai-Kastoori et al.

PLoS genetics, 10(7), e1004491-e1004491 (2014-07-11)

Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical

Global Trade Item Number

SKU	GTIN
SAB4200449-200UL	04061837772764

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