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Merck
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SAB4200607

Sigma-Aldrich

Anti-Claudin-3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Cldn3, Rat ventral prostate 1 protein (RVP1)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

form

buffered aqueous solution

species reactivity

human, rat

concentration

~1 mg/mL

technique(s)

immunoblotting: 1-2 μg/mL using A549 cells extracts
immunohistochemistry: 5-10 μg/mL using formalin-fixed, paraffin-embedded rat intestine/duodenum sections

UniProt accession no.

O15551

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLDN3(1365)
rat ... Cldn3(65130)

General description

Claudin-3 (CLDN3) is located on the human chromosome at 7q11.23.

Immunogen

a synthetic peptide corresponding to an internal sequence of rat Caludin-3, conjugated to KLH

Application

Anti-Claudin-3 antibody produced in rabbit may be used in:
  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

Biochem/physiol Actions

Anti-Claudin-3 recognizes human and rat Claudin-3.
Claudin-3 (CLDN3) promotes interactions with other cells in vivo that prevent growth and metastatic potential by assisting the expression of E-cadherin and limiting β-catenin signaling. CLDN3 represents a promising target for cancer detection, diagnosis and therapy. Overexpression of CLDN3 is associated with several neoplasias, such as ovarian, breast, prostate and pancreatic cancers. CLDN3 levels are increased in lung adenocarcinoma cells.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
054M4757V
054M4757

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Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases
Shang X, et al.
Neoplasia, 14(10), 974-IN22-974-IN22 (2012)
Williams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF2I on chromosome 7q11. 23
Hirota H, et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 5(4), 311-321 (2003)
Claudin proteins in human cancer: promising new targets for diagnosis and therapy
Morin P J
Cancer Research, 65(21), 9603-9606 (2005)
Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation
Zhang L, et al.
Testing, 8(14), 23033-23033 (2017)
Janyerkye Tulyeu et al.
Microorganisms, 7(10) (2019-10-19)
Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the contribution of

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