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SAB4200618

Monoclonal Anti-AXL antibody produced in mouse

Name: Monoclonal Anti-AXL antibody produced in mouse
Brand: SIGMA

~1.0 mg/mL, clone AXL188, purified immunoglobulin

Synonym(s):

Anti-AXL oncogene, Anti-AXL receptor tyrosine kinase, Anti-AXL transforming sequence/gene, Anti-JTK11, UFO, Anti-tyrosine-protein kinase receptor UFO

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About This Item

NACRES:

NA.44

UNSPSC Code:

12352203

Clone:

AXL188, monoclonal

Species reactivity:

human, monkey

Application:

FACS, IF

Citations:

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Properties

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AXL188, monoclonal

form

buffered aqueous solution

mol wt

antigen ~130 kDa

species reactivity

human, monkey

concentration

~1.0 mg/mL

technique(s)

flow cytometry: 20 μg/test using A549 cells, immunoblotting: 0.5-1.0 μg/mL using A549 total cell extracts, immunofluorescence: 20 μg/mL using A549 cells

isotype

IgG1

UniProt accession no.

P30530

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AXL(558)

Description

General description

Monoclonal Anti-AXL (mouse IgG1 isotype) is derived from the hybridoma AXL188 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal sequence of human AXL. AXL (Adhesion-related kinase) is a part of TAM (Tyro3, AXL and Mertk) family of receptor tyrosine kinases. Its ligand is Gas6 (Growth arrest specific gene 6). It is located on the human chromosome at 19q13.2.

Immunogen

synthetic peptide corresponding to an internal sequence of human AXL

Application

Monoclonal Anti-AXL antibody has been used in

immunoblotting
immunocytochemistry
immunofluorescence
flow cytometry

Biochem/physiol Actions

Activated AXL (Adhesion-related kinase) elicits a protective action in cells from apoptosis. It also increases migration, aggregation and growth by activating several downstream pathways. AXL has been found to play a significant role in pathogenesis and progression of human cancers including breast, hepatic cellular carcinoma, thyroid, esophageal, astrocytoma-glioblastoma. It was also suggested to serve as an important biomarker for disease status and prognosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

0000127745

0000123380

093M4832V

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Global Trade Item Number

SKU	GTIN
SAB4200618-200UL	04061837914416