Skip to Content
Merck
CN

SAB4200629

Anti-CNTNAP2 (C-terminal) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

5430425M22Rik, AUTS15, CASPR2, CDFE, CG6827, CNTNAP2, CT21123, Cell recognition molecule Caspr2 (CASPR2), Dmel CG6827, Dnrx, KIAA0868, LOC559157, NRX, NRXN4, Nrx-IV, Nx IV, PTHSL1, contactin associated protein-like 2, l(3)68Ff, l(3)rsg23, mKIAA0868, rsg23

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
Species reactivity:
rat, mouse
Technique(s):
immunoblotting: 1-2 μg/mL using whole extracts of rat brain, immunoprecipitation (IP): 2.5-5.0 μg using extracts of mouse brain
Application:
IP
Citations:
3

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

form

buffered aqueous solution

species reactivity

rat, mouse

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 1-2 μg/mL using whole extracts of rat brain, immunoprecipitation (IP): 2.5-5.0 μg using extracts of mouse brain

UniProt accession no.

Q9CPW0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... CNTNAP2(66797)
rat ... Cntnap2(500105)

General description

Contactin associated protein-like 2 (CNTNAP2) is a member of the contactin-associated protein family. It is co-localized with Shaker-like K+ channels in the juxtaparanodal region in myelinated axons. CNTNAP2 is mapped on the human chromosome at 7q35-q36.1.

Immunogen

synthetic peptide corresponding to the C-terminal region of mouse CNTNAP2

Application

Anti-CNTNAP2 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Anti-CNTNAP2 (C-terminal) recognizes mouse and rat CNTNAP2.
Contactin associated protein-like 2 (CNTNAP2) mediates interactions between neurons and glia during nervous system development and is also involved in the localization of potassium channels within differentiating axons. Mutations in the CNTNAP2 gene is associated with autism spectrum disorder (ASD). CNTNAP2 gene mutations also lead to cortical dysplasia-focal epilepsy syndrome (CDFE) and Gilles de la Tourette syndrome.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at -20 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
064M4801V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Disruption of the CNTNAP2 gene in at (7; 15) translocation family without symptoms of Gilles de la Tourette syndrome
Belloso J M, et al.
European Journal of Human Genetics, 15(6), 711-713 (2007)
Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
Poliak S, et al.
The Journal of Neuroscience, 21(19), 7568-7575 (2001)
S Poliak et al.
Neuron, 24(4), 1037-1047 (2000-01-07)
Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service