SAB4200653
Monoclonal Anti-GLUT4/SLC2A4 antibody produced in mouse
clone Glut2.6, purified from hybridoma cell culture
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About This Item
UNSPSC Code:
12352203
Clone:
Glut2.6, monoclonal
Species reactivity:
human
Application:
IF
Citations:
3
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Glut2.6, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunoblotting: 4-8 μg/mL using using whole extracts of HeLa cells., immunofluorescence: 5-10 μg/mL using using HeLa cells
isotype
IgM
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GLUT4(6517)
General description
Solute carrier family 2 member 4 (SLC2A4) is also known as glucose transporter-4 (GLUT4). It is highly expressed in adipose tissue and skeletal muscles. The gene encoding SLC2A4 is localized on human chromosome 17p13.
Immunogen
a synthetic peptide corresponding to a sequence at the C-terminal region of human GLUT4, conjugated to KLH.
Biochem/physiol Actions
Solute carrier family 2 member 4 (SLC2A4) transports glucose into cells in response to insulin. Levels of this protein have been shown to be reduced in type 2 diabetes.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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G I Bell et al.
Diabetes, 38(8), 1072-1075 (1989-08-01)
Glucose uptake by heart, skeletal muscle, and adipose tissue is acutely regulated by insulin, which stimulates facilitative glucose transport, at least in part, by promoting the translocation of transporters from an intracellular pool to the plasma membrane. cDNAs encoding the
Malgorzata Malodobra-Mazur et al.
Gene, 576(1 Pt 3), 499-504 (2015-11-04)
The glucose uptake by numerous cells like adipocytes or skeletal muscle cells requires activation of specific proteins called glucose transporters. GLUT4 content and its activation as well as SLC2A4 gene expression level are decreased in patients with type 2 diabetes.
Wei-Feng Shan et al.
Journal of Zhejiang University. Science. B, 12(8), 677-682 (2011-07-29)
Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin resistance. Glucose transporter-4 (GLUT4), one of the most important glucose transporters, plays a key role in the development of type 2
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