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Merck
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SAB4200664

Sigma-Aldrich

Anti-CT-Pro ET1 (Internal)  antibody produced in rabbit

affinity isolated antibody

Synonym(s):

C-terminal pro-endothelin 1

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41

Key Documents

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biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

form

buffered aqueous solution

mol wt

antigen ~5 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunoblotting: 0.5-1 μg/mL using C-terminal region of human recombinant CT-Pro ET1 peptide (amino acid 168-212).
immunofluorescence: 5-10 μg/mL using A549 cells
immunohistochemistry: 20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human placenta sections

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EDN1(1906)

General description

CT-Pro ET1 (C-terminal-Pro endothelin 1) is a 44 amino acid peptide.
Endothelin 1 (ET1) is an endothelium-derived peptide. It is synthesized as an inactive form of 212 amino acids and later converted to an active 21 amino acid peptide. The gene encoding it is localized on human chromosome 6p24.1.

Immunogen

a synthetic peptide corresponding to an internal region of CT-Pro ET1

Application

Anti-CT-Pro ET1 (Internal) antibody has been used in:
  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

Biochem/physiol Actions

Circulating ET-1 levels are increased in most cardiovascular diseases. The active ET-1 peptide and CT-pro-ET1 (C-terminal-Pro endothelin 1) peptide plasma levels are elevated in heart failure and after acute myocardial infarction (AMI), and give prognostic information on mortality. CTproET-1 may represent a clinically useful marker of prognosis after AMI. Nevertheless, in hemodialysis patients, CT-pro-ET1 concentrations were not associated at all with mortality.
Endothelin 1 (ET1) is a vasoconstrictor and is involved in pulmonary vascular homeostasis. ET1 has been linked to HIV (human immunodeficiency virus)-associated pulmonary arterial hypertension and endothelial dysfunction.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
075M4849V

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Sohail Q Khan et al.
American heart journal, 154(4), 736-742 (2007-09-26)
Endothelin-1 is elevated in heart failure (HF) and after acute myocardial infarction (AMI) and gives prognostic information on mortality. Another part of its precursor, C-terminal pro-endothelin-1 (CT-proET-1), is more stable in circulation and ex vivo. We investigated the cardiovascular prognostic
Ferruh Artunc et al.
PloS one, 9(1), e86148-e86148 (2014-01-28)
Vasopressin, endothelin and adrenomedullin are vasoactive peptides that regulate vascular tone and might play a role in hypertensive diseases. Recently, laboratory assays have been developed to measure stable fragments of vasopressin, endothelin and adrenomedullin. Little is known about their diagnostic
Rushi V Parikh et al.
PloS one, 11(1), e0146355-e0146355 (2016-01-12)
HIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis. Higher levels of ET-1 predict disease severity and mortality in other forms of
Alexandra B Cooke et al.
Metabolism: clinical and experimental, 64(9), 1103-1111 (2015-07-05)
Endothelin-1 (ET-1) is a potent vasoconstrictor produced by vascular endothelial cells, and a known marker of endothelial dysfunction. However, the acute and chronic effects of smoking and nicotine gum on the ET-1 response to acute physical stress in young healthy
Abdelkader Chalghoum et al.
BMC cardiovascular disorders, 15, 152-152 (2015-11-18)
Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms. Our study aims to evaluate the endothelin-1 (ET-1) serum concentration in Tunisian coronary

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