Monoclonal Anti-Multimerin-2 antibody produced in mouse

Monoclonal Anti-Multimerin-2 (mouse IgG1 isotype) is derived from the hybridoma MM-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Multimerin-2 (MMRN2) belongs to the EMI domain endowed (EDEN) protein family. It is located in the blood vessels and is a glycoprotein. MMRN2 gene is mapped on the human chromosome at 10q23.2.

Multimerin-2 (MMRN2) is an extracellular matrix glycoprotein. The protein contains a signal sequence, an amino-terminal EMI (cysteine-rich) domain and a carboxyl-terminal C1q (complement 1)-like domain. MMRN2 is also referred to as endoglyx-1.

a recombinant protein of human Multimerin-2

Monoclonal Anti-Multimerin-2 antibody produced in mouse may be used in immunoblotting and immunofluorescence.

Monoclonal Anti-Multimerin-2 recognizes human Multimerin-2.

Multimerin-2 (MMRN2) negatively regulates the angiogenesis regulators vascular endothelial growth factor receptor 1 & 2 (VEGFR 1 & 2). It plays a role in the maintenance of blood vessels homeostasis, regulation of endothelial cell (EC) function and hence tumor growth arrest.

Multimerin-2 (MMRN2) regulates endothelial cell migration and neo-angiogenesis through interaction with VEGF-A (vascular endothelial growth factor-A).

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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