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Merck
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SAB4200677

Monoclonal Anti-HAVCR1 antibody produced in mouse

clone KM-23, purified from hybridoma cell culture

Synonym(s):

HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, hepatitis A virus cellular receptor 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
KM-23, monoclonal
Application:
IF, IHC
Citations:
3

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

KM-23, monoclonal

form

buffered aqueous solution

mol wt

antigen 38 kDa

species reactivity

human, rat

concentration

~1 mg/mL

technique(s)

immunoblotting: 2-4 μg/mL using whole extract of human 769-P cells., immunofluorescence: 1-2 μg/mL using human 769-P cells., immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human kidney sections and Biotin/ExtrAvidin®-Peroxidase staining system.

isotype

IgG2a

UniProt accession no.

Q96D42

shipped in

dry ice

Gene Information

human ... HAVCR1(26762)
rat ... Havcr1(286934)

target post-translational modification

unmodified

General description

Monoclonal Anti-HAVCR1 (mouse IgG2a isotype) is derived from the KM-23 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse BALB/c mice. Hepatitis A virus cellular receptor 1 (HAVCR1) belongs to the T-cell immunoglobulin mucin (TIM)-family proteins. Human HAVCR1 is predominantly expressed in epithelial and T helper (TH) cells. It is a transmembrane type I epithelial cell protein. HAVCR1 is composed of immunoglobulin (Ig)-like domain and mucin domains in its ectodomain.

Immunogen

a synthetic peptide corresponding to a sequence at the internal region of human HAVCR1

Application

Monoclonal Anti-HAVCR1 antibody produced in mouse may be used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

Hepatitis A virus cellular receptor 1 (HAVCR1) enhances infection of several virus types such as filovirus, alphavirus, flavivirus and arenavirus due to its involvement in glycoproteins dependent and independent attachment of viral particles to cell membrane. HAVCR1 also inhibits human immunodeficiency virus-1 (HIV-1) replication in CD4+ T cells and inhibit additional virus release, including murine leukemia virus (MLV) and Ebola virus (EBOV) through its phosphatidylserine (PS) receptor. It is involved in cell proliferation and apoptotic body uptake. HAVCR1 expression is increased in proximal tubule epithelial cells in the kidney during ischemic acute renal failure.
Monoclonal Anti-HAVCR1 recognizes human and rat HAVCR1.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Legal Information

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
036M4833V

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Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein
Nakajima T, et al.
Genes and Immunity, 6(5), 398-406 (2005)
Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions
Tami C, et al.
Journal of virology, 81(7), 3437-3446 (2007)
Molecular biomarker candidates of acute kidney injury in zero-hour renal transplant needle biopsies
Korbely R, et al.
Transplant International : Official Journal of the European Society For Organ Transplantation, 24(2), 143-149 (2011)

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