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Merck
CN

SAB4200737

Sigma-Aldrich

Anti-MART-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-MART-1, Anti-MART1, Anti-MLANA, Anti-Melanoma antigen recognized by T-cells 1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

Key Documents

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biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~13 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 2-4 μg/mL using human melanoma SK-Mel-28 cell line extract
immunofluorescence: 0.25-0.5 μg/mL using human melanoma SK-Mel-28 cell line
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human melanoma sections

UniProt accession no.

Q16655

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MART-1(2315)

General description

Anti-MART-1 is produced in rabbit using a synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to keyhole limpet hemocyanin (KLH). Melanoma antigen recognized by T-cells 1 (MART-1), also known as melan-A antigen, LB39-AA or antigen SK29-AA, is a type III signal-anchor protein that is localized mainly to the endoplasmic reticulum, the trans-Golgi network and melanosomes. MART-1 protein is expressed specifically in normal skin, retina, melanocyte cell lines and melanomas. It is a melanoma antigen recognized by T-cells and belongs to the melanocyte differentiation markers.

Immunogen

synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to KLH

Application

Anti-MART-1 antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

Melanoma antigen recognized by T-cells 1 (MART-1) is specifically recognized by human leukocyte antigen (HLA-A2) restricted tumor-infiltrating T lymphocytes (TIL-1) in melanoma patients and is suggested to be involved in tumor progression. It is also involved in pigmentation process and is suggested as a candidate marker for albinism.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
017M4833V
51160812

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Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas
Chen YT, et al.
Proceedings of the National Academy of Sciences of the USA, 93(12), 5915-5919 (1996)
The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins
De MAM, et al.
Traffic, 3(9), 678-693 (2002)
Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas
Takeuchi H, et al.
Cancer Research, 63(2), 441-448 (2003)

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