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Merck
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SAB4300050

Sigma-Aldrich

Anti-phospho-BAD (pSer112) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BBC2 antibody produced in rabbit, Anti-BCL2-associated agonist of cell death antibody produced in rabbit, Anti-BCL2L8 antibody produced in rabbit

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About This Item

MDL number:
MFCD02097155
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~23 kDa

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(H-S-SP-Y-P)

NCBI accession no.

NP_004313.1

UniProt accession no.

Q92934

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer112)

Gene Information

human ... BAD(572)

General description

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Immunogen

Peptide sequence around phosphorylation site of serine 112 (H-S-S(p)-Y-P), according to the protein BAD.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
511711067

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Yuichi Sawaguchi et al.
Anticancer research, 37(8), 4051-4057 (2017-07-26)
The serine/threonine Pim kinases are overexpressed in various types of solid carcinomas and hematological malignancies, and contribute to regulating cell-cycle progression and cell survival. The aim of this study was to discover a novel pan-Pim kinases inhibitor with potent anti-proliferative
Yuichi Sawaguchi et al.
Frontiers in pharmacology, 12, 672536-672536 (2021-05-21)
Pim kinases are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Here in this study, we investigated the preclinical profile of novel pan-Pim kinase inhibitors with imidazopyridazine and thiazolidinedione structure. Imidazopyridazine-thiazolidinediones inhibited

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