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SAB4300420

Sigma-Aldrich

Anti-CDKN1B (Ab-10) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-CDKN4 antibody produced in rabbit, Anti-KIP1 antibody produced in rabbit, Anti-MEN1B antibody produced in rabbit, Anti-MEN4 antibody produced in rabbit, Anti-cyclin-dependent kinase inhibitor 1B (p27, Kip1) antibody produced in rabbit
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~27 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(N-G-S-P-S)

NCBI accession no.

NP_004055.1

UniProt accession no.

P46527

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDKN1B(1027)

Immunogen

Peptide sequence around aa. 8-12 (N-G-S-P-S), according to the protein CDKN1B.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Clarissa Silva Martins et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 52(2), 117-123 (2020-02-14)
Corticotroph adenomas frequently harbor somatic USP8 mutations. These adenomas also commonly exhibit underexpression of P27, a cell cycle regulator. The present study aimed to determine the influence of USP8 mutations on clinical features of Cushing's disease and to elucidate the

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