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SAB4300427

Anti-PAK1 (Ab-212) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC130000 antibody produced in rabbit, Anti-MGC130001 antibody produced in rabbit, Anti-PAKalpha antibody produced in rabbit, Anti-p21 protein (Cdc42 / Rac)-activated kinase 1 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD03457569
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p), WB
Citations:
3
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~68 kDa

species reactivity

human, mouse, rat

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-V-T-P-T)

NCBI accession no.

NP_001122092.1

UniProt accession no.

Q13153

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PAK1(5058)

General description

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Immunogen

Peptide sequence around aa. 210-214 (P-V-T-P-T), according to the protein PAK1.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Certificates of Analysis (COA)

Lot/Batch Number
871521160

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Matthew Rettig et al.
PloS one, 7(7), e42012-e42012 (2012-08-01)
The role of c-Crk (CRK) in promoting metastasis is well described however the role of CRK phosphorylation and the corresponding signaling events are not well explained. We have observed CRK-II serine 41 phosphorylation is inversely correlated with p120-catenin and E-cadherin
Fariborz Mortazavi et al.
BMC cancer, 15, 381-381 (2015-05-10)
Key effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC). We used NSCLC clinical specimens to
Gholam H Pezeshkpour et al.
Genes & cancer, 4(7-8), 315-324 (2013-10-30)
CRK (c-Crk) as an adaptor protein is involved in several oncogenic signal transduction pathways, conveying oncogenic signals to its downstream effectors and thereby affecting multiple cellular processes including proliferation, differentiation, and migration. For example, we have observed that CRK expression

Global Trade Item Number

SKUGTIN
SAB4300427-100UG04061833477229