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Merck
CN

SAB4300435

Anti-NOS3 (Ab-1177) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-ECNOS antibody produced in rabbit, Anti-eNOS antibody produced in rabbit, Anti-nitric oxide synthase 3 (endothelial cell) antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00675266
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
6

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~140 kDa

species reactivity

human, mouse, rat

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(T-Q-S-F-S)

NCBI accession no.

NP_000594.2

UniProt accession no.

P29474

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NOS3(4846)

General description

NOS3 (nitric oxide synthase 3) is located on human chromosome 7q36.
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Immunogen

Peptide sequence around aa. 1175-1179 (T-Q-S-F-S), according to the protein NOS3.

Application

Anti-NOS3 (Ab-1177) antibody has been used in western blotting.

Biochem/physiol Actions

Modifications in the NOS3 (nitric oxide synthase 3) gene leads to erectile dysfunction susceptibility, age of onset and severity. In heart, NOS3 helps in NO (nitric oxide) synthesis. It also controls vascular tone and blood pressure.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871521170

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Functional Variations in the NOS3 Gene Are Associated With Erectile Dysfunction Susceptibility, Age of Onset and Severity in a Han Chinese Population
Yang B, et al.
Journal of Sexual Medicine, 14(4), 551-557 (2017)
Endothelial nitric oxide synthase gene single nucleotide polymorphisms and the risk of hypertension: A meta-analysis involving 63,258 subjects
Xie X, et al.
Clinical and Experimental Hypertension, 39(2), 175-182 (2017)
Gestational diabetes and the adenosine/L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium
San Martin R and Sobrevia L
Placenta, 27(1), 1-10 (2006)
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency
Ichinose F, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 286(3), H1070-H1075 (2004)
Gang Ren et al.
Scientific reports, 9(1), 6688-6688 (2019-05-02)
One third of newly diagnosed breast cancers in the US are early-stage lesions. The etiological understanding and treatment of these lesions have become major clinical challenges. Because breast cancer risk factors are often linked to aberrant nitric oxide (NO) production
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