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Merck
CN

SAB4300592

Anti-PXN (Ab-88) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ16691 antibody produced in rabbit, Anti-paxillin antibody produced in rabbit

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-PXN (Ab-88) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~68 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-V-Y-G-S)

NCBI accession no.

NP_001074324.1

UniProt accession no.

P49023

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PXN(5829)

Application

Anti-PXN (Ab-88) antibody has been used in immunofluorescence.

Biochem/physiol Actions

Paxillin (PXN) controls signal transduction, cell morphology and motility, cytoskeletal rearrangements, proliferation and apoptosis. It serves as an oncogene, hence it plays a major role in the growth of human carcinomas.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
PXN (paxillin) is a focal adhesion-associated tyrosine-based protein, that is present in the cytoplasm. It is a 68kDa protein that is located on chromosome 12q24.

Immunogen

Peptide sequence around aa. 86-90 (P-V-Y-G-S), according to the protein PXN.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
951421538

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Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells
Du C, et al.
Oncology Reports, 35(1), 409-417 (2016)
Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti
Carlisle FA, et al.
Gene Expression Patterns, 12(5-6), 172-179 (2012)
Expression of paxillin in laryngeal squamous cell carcinoma and its prognostic value
Li L, et al.
International Journal of Clinical and Experimental Pathology, 8(8), 9232-9239 (2015)
Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients
Zhao CJ, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 1989-1995 (2015)
The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells
Maier B, et al.
Cell Cycle, 12(9), 1457-1471 (2013)
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