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Merck
CN

SAB4300676

Anti-Vimentin Antibody

rabbit polyclonal

Synonym(s):

Anti-FLJ36605, Anti-VIM

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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Product Name

Anti-Vimentin antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~57 kDa

species reactivity

monkey, mouse, human, rat

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-Q-V-I-N)

NCBI accession no.

NM_003380.3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... Vimentin(7431)

General description

Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. It is located on human chromosome 10p13.

The antibody detects endogenous level of total Vimentin protein.
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.

Immunogen

Peptide sequence around aa. 452-456 (G-Q-V-I-N), according to the protein NP_003371.2

Biochem/physiol Actions

Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871521488

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Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions
Schafer G, et al.
Journal of Virology (2017)
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins
Liu PF, et al.
PLoS ONE (2017)
The gene encoding human vimentin is located on the short arm of chromosome 10
Ferrari S, et al.
American Journal of Human Genetics (1987)
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks
Janmey PA, et al.
The Journal of Cell Biology (1991)
Esther Natalia Muñoz et al.
Biochemistry and biophysics reports, 27, 101027-101027 (2021-06-24)
ROCK2 is a protein involved in the restructuring of the cytoskeleton in cell adhesion and contractibility processes. miR-138-5p and miR-455-3p regulate Rock2 expression, cell proliferation, migration, and invasion in different experimental cell models. However, their participation in the cytoarchitecture and
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