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Merck
CN

SAB4300870

Anti-Histone H4R3me2s antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FO108, H4, H4/n, H4F2, H4FN

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Histone H4R3me2s antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

11 kDa

species reactivity

rat, mouse, human

concentration

1.0 mg/mL

technique(s)

immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)

isotype

IgG

accession no.

NP_003539.1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

dimethylation (Arg3)

Quality Level

100

Gene Information

human ... HIST2H4A(8370)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Immunogen

A synthetic peptide corresponding to the amino terminus of histone H4 in which Arg3 is di-methylated.

Physical form

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
20D28HW027
20617HW027
H1105HW027

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Satya K Kota et al.
Bone, 117, 37-46 (2018-09-07)
Protein arginine methyltransferases (PRMTs) catalyze symmetric and asymmetric methylation on arginine residues of multiple protein targets including histones and have essential roles in organismal development and disease. PRMT5 mediates symmetric di-methylation (sDMA) of arginine 2 (H3R2me2s) and arginine 8 on
Zhiwei Zheng et al.
Journal of pharmaceutical analysis, 13(6), 590-602 (2023-07-13)
This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5 (PRMT5) in cisplatin-induced hearing loss. The effects of PRMT5 inhibition on cisplatin-induced auditory injury were determined using immunohistochemistry, apoptosis assays, and auditory brainstem response. The mechanism
Stephanie A Amici et al.
Frontiers in immunology, 12, 695947-695947 (2021-06-26)
Multiple Sclerosis (MS) is a debilitating central nervous system disorder associated with inflammatory T cells. Activation and expansion of inflammatory T cells is thought to be behind MS relapses and influence disease severity. Protein arginine N-methyltransferase 5 (PRMT5) is a
PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
Lewis, et al.
Journal of immunology (Baltimore, Md. : 1950), 208, 1525-1533 (2023)

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