SAB4301061
Anti-INTS1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
INT1, NET28
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About This Item
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
concentration
1.3 mg/mL
technique(s)
immunohistochemistry: 1:25- 1:100
isotype
IgG
accession no.
NP_001073922.2
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... INTS1(26173)
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Immunogen
Synthetic peptide corresponding to residues near the N terminal of human integrator complex subunit 1
Application
Anti-INTS1 antibody produced in rabbit is suitable for immunohistochemistry studies at a dilution of 1:25 - 1:100.
Biochem/physiol Actions
INTS1 (Integrator complex subunit 1), a large nuclear protein, involved in the processing of small nuclear RNA as a major component of the Integrator complex. During transcriptional regulation and in RNA processing, it directly binds to the C-terminal domain of the RNA polymerase II largest subunit. It has been reported that INTS1 is also involved in different cell support processes such as the formation of a scaffold for the assembly of integrator complex.
The antibody detects endogenous levels of total INTS1 protein.
Features and Benefits
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Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Toshiyuki Hata et al.
Biochimica et biophysica acta, 1773(7), 1039-1051 (2007-06-05)
The KIAA1440 protein contains no significant domains that allow for a prediction of its function, despite the fact that it is an extremely large protein comprising 2222 amino acids. In our current study, we show that the developing KIAA1440(-/-) mouse
David Baillat et al.
Cell, 123(2), 265-276 (2005-10-22)
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is an essential component of transcriptional regulation and RNA processing of protein-coding genes. A large body of data also implicates the CTD in the transcription and processing of RNAPII-mediated small nuclear
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