SAB4301170
Anti-pan-AKT antibody produced in rabbit
affinity isolated antibody
Synonym(s):
PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-pan-AKT antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
56 kDa
species reactivity
rat, human, mouse
concentration
2 mg/mL
technique(s)
western blot: 1:500-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_001014431.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AKT1(207)
Application
Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia.
The antibody detects endogenous levels of total pan-AKT protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase
Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
Cho H, et al.
The Journal of Biological Chemistry, 276, 38349-38352 (2001)
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM, et al.
Genetics and molecular research : GMR, 16 (2017)
Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake
Shimoda Y, et al.
Endocrinology, 156, 3548-3558 (2015)
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Emamian ES, et al.
Nature Genetics, 36, 131-137 (2004)
AKT plays a central role in tumorigenesis.
Testa JR
Proceedings of the National Academy of Sciences of the USA, 98, 10983-10985 (2001)
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