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Merck
CN

SAB4301248

Anti-phospho-Pim-1 (pTyr309) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

EC 2.7.11.1, PIM-1, Proto-oncogene serine/threonine-protein kinase pim-1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
mouse, rat, human
Application:
WB
Citations:
1

Key Documents

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isotype

IgG

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

45 kDa

species reactivity

mouse, rat, human

concentration

1.0 mg/mL

technique(s)

western blot: 1:500-1:1000 (Cell Lysate)

accession no.

NP_001230115.1

UniProt accession no.

P11309

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr309)

Gene Information

human ... PIM1(5292)

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General description

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) is expressed at high levels in bone marrow, thymus, spleen, fetal liver, hippocampus, oral epithelium, and the prostate gland. PIM1 gene has five introns and six exons and is mapped to human chromosome 6p21.2.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.

Biochem/physiol Actions

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) modulates cell cycle progression, cellular division, differentiation, and apoptosis. It participates in genomic instability. PIM1 serves as an oncogenic survival factor. PIM1 gene is overexpressed in gastric carcinoma, squamous cell carcinoma, colorectal carcinoma, liver carcinoma, liposarcoma, and bladder cancer.
The antibody detects endogenous levels of Pim-1 only when phosphorylated at tyrosine 309.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
461211677

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PIM1 (pim-1 oncogene)
Sai-Ching JY
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2013)

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