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SAB4301399

Anti-phospho-DRP1 (pSer637) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

DLP1, DNM1L, DRP1, DVLP, Dymple

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-phospho-DRP1 (pSer637) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

82 kDa

species reactivity

human

concentration

1.0 mg/mL

technique(s)

western blot: 1:500-1:1000 (Cell Lysate)

isotype

IgG

accession no.

NP_036192.2.

UniProt accession no.

O00429

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer637)

Quality Level

100

Gene Information

human ... DNM1L(10059)

Application

Anti-phospho-DRP1 (pSer637) antibody produced in rabbit has been used in immunoblotting and western blotting.

Biochem/physiol Actions

Dynamin related protein 1 (DRP1) is an important regulator of mitochondrial fission and peroxisomal division. It regulates proper mitochondrial function, apoptosis and necrosis. Mutations in this gene is associated with Alzheimer′s disease.
The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Dynamin related protein 1 (DRP1) is a dynamin-related guanosine triphosphatase. The gene is located on human chromosome 12p11.21. DRP1 is a cytosolic protein, which is also present on the outer mitochondrial membrane.

Immunogen

Peptide sequence around phosphorylation site of Serine637(K-L-S(p)-A-R) derived from Human DRP1.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
461211842

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S-nitrosylation of Drp1 mediates ?-amyloid-related mitochondrial fission and neuronal injury
Cho DH, et al.
Science, 324(5923), 102-105 (2009)
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells
Huang Y and Hu Z
Journal of Cellular Physiology, 233(9), 7480-7496 (2018)
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum
Ji WK, et al.
The Journal of Cell Biology, 216(12), 4123-4139 (2017)
Downregulation of Drp1, a fission regulator, is associated with human lung and colon cancers
Kim YY, et al.
Acta biochimica et biophysica Sinica, 50(2), 209-215 (2018)
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells
Gomez-Lazaro, et al.
Free Radical Biology & Medicine, 44(11), 1960-1969 (2008)
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