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Merck
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SAB4500110

Anti-C/EBP-α antibody produced in rabbit

affinity isolated antibody

Synonym(s):

C/EBP α, CCAAT/enhancer binding protein α, CCAAT/enhancer binding protein (C/EBP) α, CEBPA

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 37 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

P49715

UniProt accession no.

P49715

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CEBPA(1050)

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General description

Anti-C/EBP-α Antibody detects endogenous levels of total C/EBP-α protein.
CCAAT/enhancer-binding protein α (C/EBPα) is encoded by the gene mapped to human chromosome 19q13.1. The encoded protein belongs to the basic leucine zipper (bZIP) family of transcription factors. CEBPA is highly expressed in differentiated tissues.

Immunogen

The antiserum was produced against synthesized peptide derived from human C/EBP-alpha.

Immunogen Range: 6-55

Biochem/physiol Actions

The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) plays an essential role in tumor progression. It blocks β-catenin to repress lung adenocarcinoma cell invasion and migration. CEBPA is implicated in the regulation of hematopoiesis and terminal differentiation of various cell types like adipocytes, hepatocytes and different epithelial cells. Variations in the gene expression has been observed in 5–10% of cases of acute myeloid leukemia (AML).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
210056

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CEBPA-double mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features.
Mannelli F, et al.
Haematologica (2016)
C/EBPα Suppresses Lung Adenocarcinoma Cell Invasion and Migration by Inhibiting β-Catenin.
Lu J, et al.
Cellular Physiology and Biochemistry, 42(5), 1779-1788 (2017)
The significance of c. 690G> T polymorphism (rs34529039) and expression of the CEBPA gene in ovarian cancer outcome.
Konopka B, et al.
Oncotarget, 7(41), 67412-67412 (2016)

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