SAB4500418
Anti-GPR151 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
G-protein coupled receptor PGR7, GPCR-2037, GPR151, PGR7, Probable G-protein coupled receptor 151
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GPR151(134391)
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General description
G protein-coupled receptor 151 (GPR151) is encoded by the gene mapped to human chromosome 5. It belongs to the A type of G protein-coupled receptor (GPCR) family and it shows homology with galanin receptor 2 and 3. In mice, GPR151 transcript is highly and specifically expressed in habenular neurons.
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR151.
Immunogen Range: 370-419
Immunogen Range: 370-419
Application
Anti-GPR151, C-Terminal antibody produced in rabbit has been used for Western blotting.
Biochem/physiol Actions
G protein-coupled receptor 151 (GPR151) is a highly conserved protein, and acts as a potential target for psychiatric drug development, due to its expression in habenular neurons which may be critically involved in the pathophysiology of psychiatric disorders such as addiction and depression. Experimental studies reveal that GPR151 might play a neuroprotective and/or pro-regenerative role in the dorsal root ganglion (DRG) after nerve injury.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Yuxiao Yao et al.
Molecular neurobiology (2023-07-21)
Histamine receptors mediate important physiological processes and take part in the pathophysiology of different brain disorders. Histamine receptor 1 (HRH1) is involved in the development of neurotransmitter systems, and its role in neurogenesis has been proposed. Altered HRH1 binding and
Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.
Broms J, et al.
The Journal of Comparative Neurology, 523(3), 359-380 (2015)
Nisa Roy et al.
Scientific reports, 11(1), 5549-5549 (2021-03-12)
G-protein coupled receptor 139 (GPR139) is an evolutionarily conserved orphan receptor, predominantly expressing in the habenula of vertebrate species. The habenula has recently been implicated in aversive response and its associated learning. Here, we tested the hypothesis that GPR139 signalling
Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.
Holmes FE, et al.
Molecular and Cellular Neurosciences, 78, 35-40 (2017)
Jonas Broms et al.
The Journal of comparative neurology, 523(3), 359-380 (2014-08-15)
The habenula is a phylogenetically conserved brain structure in the epithalamus. It is a major node in the information flow between fronto-limbic brain regions and monoaminergic brainstem nuclei, and is thus anatomically and functionally ideally positioned to regulate emotional, motivational
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