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Merck
CN

SAB4500430

Anti-CPB2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CBPB2, CPU, carboxypeptidase B2, carboxypeptidase U, plasma carboxypeptidase B

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
2
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, western blot: 1:500-1:1000

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CBPB2(1361)

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General description

Anti-CPB2 Antibody detects endogenous levels of total CPB2 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human CPB2.

Immunogen Range: 321-370

Application

Anti-CPB2, C-Terminal antibody produced in rabbit is suitable for indirect ELISA and western blot analysis.

Biochem/physiol Actions

CPB2 exhibit antifibrinolytic property. It cleaves the C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins to regulate their activities. By the carboxypeptidase activity, CPB2 release C-terminal Lys and Arg residues from partially degraded fibrin which finally indicates towards an antifibrinolytic effect.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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S S Mao et al.
The Journal of biological chemistry, 274(49), 35046-35052 (1999-11-27)
Plasma carboxypeptidase B (PCB) is an exopeptidase that exerts an antifibrinolytic effect by releasing C-terminal Lys and Arg residues from partially degraded fibrin. PCB is produced in plasma via limited proteolysis of the zymogen, pro-PCB. In this report, we show
D L Eaton et al.
The Journal of biological chemistry, 266(32), 21833-21838 (1991-11-15)
A novel plasminogen-binding protein has been isolated from human plasma utilizing plasminogen-Sepharose affinity chromatography. This protein copurified with alpha 2 antiplasmin when the plasminogen affinity column was eluted with high concentrations of epsilon-aminocaproic acid (greater than 20 mM). Analysis by

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