SAB4500579
Anti-Cytochrome P450 1A1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
AHH, AHRR, CP11, CYP1, CYPIA1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 58 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CYP1A1(1543)
General description
Anti-Cytochrome P450 1A1 Antibody detects endogenous levels of total Cytochrome P450 1A1 protein.
The cytochrome P450 family 1 subfamily A member 1 (CYP1A1) gene with seven exons, is mapped to human chromosome 15q24.1. The encoded protein is primarily expressed in extrahepatic tissues.
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 1A1/2.
Immunogen Range: 71-120
Immunogen Range: 71-120
Biochem/physiol Actions
Cytochrome P450 family 1 subfamily A member 1 (CYP1A1) catalyzes 2-OH hydroxylation in the endometrium. In addition, it also catalyzes the oxidation of various structurally unrelated compounds, such as steroids and fatty acids. CYP family members play an important role in metabolic activation and detoxification of tobacco-derived carcinogen and other xenobiotics. CYP1A1 also facilitates drug metabolism. Mutation in the gene increases the risk of susceptibility to colorectal cancer and acute lymphoblastic leukemia (ALL).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
Hirata H, et al.
Cancer, 112(9), 1964-1973 (2008)
Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population.
Yousef AM, et al.
Molecular Biology Reports, 39(10), 9423-9433 (2012)
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: A meta-analysis
Jin JQ, et al.
World Journal of Gastroenterology, 17(2), 260-260 (2011)
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
Ouerhani S, et al.
Molecular Biology Reports, 40(2), 1307-1314 (2013)
An additional case of the recurrent 15q24. 1 microdeletion syndrome and review of the literature.
Ng I S, et al.
Twin Research and Human Genetics : The Official Journal of the International Society for Twin Studies, 14(4), 333-339 (2011)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service