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Merck
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SAB4500688

Anti-EDG1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

EDG1, S1P1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg-1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 42 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

NCBI accession no.

P21453

UniProt accession no.

P21453

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... S1PR1(1901)

General description

Anti-EDG1 Antibody detects endogenous levels of total EDG1 protein.
EDG1 (endothelial differentiation gene )/S1P1 (sphingosine-1-phosphate receptor 1) is a transmembrane G protein coupled receptor. It belongs to the endothelial differentiation gene (EDG) family of receptors. It is mapped to human chromosome 1p21.

Immunogen

The antiserum was produced against synthesized peptide derived from human EDG1.

Immunogen Range: 5-54

Biochem/physiol Actions

EDG1 (endothelial differentiation gene )/S1P1 (sphingosine-1-phosphate receptor 1) serve as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It is involved in angiogenesis and lymphangiogenesis. It also acts as a pro-tumorigenic receptor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
61082

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S1PR1 mediates anti?apoptotic/pro?proliferative processes in human acute myeloid leukemia cells
Xu XQ, et al.
Molecular Medicine Reports, 14(4), 3369-3375 (2016)
Mohamad Adada et al.
The FEBS journal, 280(24), 6354-6366 (2013-07-25)
Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein-coupled receptors, specifically five S1P receptors (S1PRs). The identified S1PRs differ

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