SAB4500954
Anti-SEPT8 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
KIAA0202, Septin-8
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SEPT8(23176)
General description
Anti-SEPT8 Antibody detects endogenous levels of total SEPT8 protein.
Septins are cytoskeletal GTPases. SEPT8 (septin 8) belongs to septin family. It is expressed in brain. It is also present in heart, aorta, prostate, testis and ovary. It is located on human chromosome 5q31.
Immunogen
The antiserum was produced against synthesized peptide derived from human SEPT8.
Immunogen Range: 170-219
Immunogen Range: 170-219
Biochem/physiol Actions
In platelets, SEPT8 (septin 8) participates in granula secretion. It also participates in cytokinesis, vesicle trafficking and exocytosis. The protein mitogen-activated protein kinase-activated protein kinase 5 (MK5) phosphorylates and modulates septin 8, which interacts with various synaptic vesicle proteins and may participate in the release of neurotransmitters.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Septin 8 is an interaction partner and in vitro substrate of MK5
Shiryaev A, et al.
World Journal of Biological Chemistry, 3, 98-109 (2012)
Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5
Blaser S, et al.
The Journal of Pathology, 210, 103-110 (2006)
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Naka I, et al.
Malaria Journal (2009)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4500954-100UG | 04061835712427 |