SAB4501317
Anti-MYLIP antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Inducible degrader of the low-density lipoprotein receptor, E3 ubiquitin-protein ligase MYLIP, MIR, Myosin regulatory light chain-interacting protein
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 49 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYLIP(29116)
General description
The MYLIP (myosin regulatory light chain interacting protein) gene is mapped to human chromosome 6p22.3. The encoded protein is an E3 ubiquitin ligase, expressed in all tissues including hippocampus and cerebellum. Anti-MYLIP antibody detects endogenous levels of total MYLIP protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human MYLIP.
Immunogen Range: 161-210
Immunogen Range: 161-210
Application
Anti-MYLIP antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
MYLIP (myosin regulatory light chain interacting protein) controls the LDLR (low density lipoprotein receptor) activity and stability, which might change due to fluctuation in the intracellular cholesterol levels. Mylip is associated with brain development. It induces platelet-derived growth factor (PDGF) signaling in fibroblasts. Mylip is also called as inducible degrader of the LDL-R (Idol), as it leads to receptor degradation, especially in macrophages and liver. It might serve as a target for drug development in disease.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(7), 1154-1166 (2017-03-25)
The kidney plays a central role in elimination of metabolic waste products and regulation of low-molecular weight metabolites via glomerular filtration, tubular secretion and reabsorption. Disruption of these processes results in profound changes in the biochemical milieu of the body
Mylip makes an Idol turn into regulation of LDL receptor
Lindholm D, et al.
Cellular and Molecular Life Sciences, 66(21), 3399-3402 (2009)
Shuman Liu et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(3), 538-543 (2013-10-30)
Nephrotic syndrome (NS) leads to elevation of serum total and LDL cholesterol. This is largely due to impaired LDL clearance, which is caused by hepatic LDL receptor (LDLR) deficiency despite normal LDLR mRNA expression, pointing to a post-transcriptional process. The
RP1-13d10. 2 is a novel modulator of statin-induced changes in cholesterol
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Circulation: Genomic and Precision Medicine, 9(3), 223-230 (2016)
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