SAB4501317
Anti-MYLIP antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Inducible degrader of the low-density lipoprotein receptor, E3 ubiquitin-protein ligase MYLIP, MIR, Myosin regulatory light chain-interacting protein
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human, mouse, rat
Citations:
9
Technique(s):
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Uniprot accession no.:
Product Name
Anti-MYLIP antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 49 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYLIP(29116)
Application
Anti-MYLIP antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
MYLIP (myosin regulatory light chain interacting protein) controls the LDLR (low density lipoprotein receptor) activity and stability, which might change due to fluctuation in the intracellular cholesterol levels. Mylip is associated with brain development. It induces platelet-derived growth factor (PDGF) signaling in fibroblasts. Mylip is also called as inducible degrader of the LDL-R (Idol), as it leads to receptor degradation, especially in macrophages and liver. It might serve as a target for drug development in disease.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
The MYLIP (myosin regulatory light chain interacting protein) gene is mapped to human chromosome 6p22.3. The encoded protein is an E3 ubiquitin ligase, expressed in all tissues including hippocampus and cerebellum. Anti-MYLIP antibody detects endogenous levels of total MYLIP protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human MYLIP.
Immunogen Range: 161-210
Immunogen Range: 161-210
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mylip makes an Idol turn into regulation of LDL receptor
Lindholm D, et al.
Cellular and Molecular Life Sciences, 66(21), 3399-3402 (2009)
Short-term use of atorvastatin affects glucose homeostasis and suppresses the expression of LDL receptors in the pancreas of mice
Yu Q, et al.
Molecular Medicine Reports, 18(3), 2780-2788 (2018)
Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations
Yan TT, et al,
Lipids in Health and Disease, 11(1), 141-141 (2012)
RP1-13d10. 2 is a novel modulator of statin-induced changes in cholesterol
Mitchel K, et al.
Circulation: Genomic and Precision Medicine, 9(3), 223-230 (2016)
Shuman Liu et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(3), 538-543 (2013-10-30)
Nephrotic syndrome (NS) leads to elevation of serum total and LDL cholesterol. This is largely due to impaired LDL clearance, which is caused by hepatic LDL receptor (LDLR) deficiency despite normal LDLR mRNA expression, pointing to a post-transcriptional process. The
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