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SAB4501320

Anti-GTPase Activating Protein antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GTPase activating protein, GTPase activating protein ID-GAP, MGCRACGAP variant α, MGCRACGAP variant β, RAC GTPase- activating protein 1

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD00162333
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 71 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

NCBI accession no.

Q9H0H5

UniProt accession no.

Q9H0H5

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... RACGAP1(29127)

General description

Rac GTPase activating protein 1 (RacGAP1) is a GTPase activating protein, encoded by the gene mapped to human chromosome 12q13.12. The encoded protein is a key constituent of the central spindling.
Anti-GTPase Activating protein Antibody detects endogenous levels of total GTPase Activating protein protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human GTPase Activating Protein.

Immunogen Range: 353-402

Biochem/physiol Actions

GTPase activating protein/ Rac GTPase activating protein 1 (RacGAP1) plays a vital role in regulation of various cellular processes, including cytokinesis, transformation, invasive migration, metastasis and cell differentiation. In male germ cells, the encoded protein controls the function of Rho proteins such as Rac and cdc42 to influence cell morphology, motility and establishment of polarity. RacGAP1 is also implicated in the growth and differentiation of hematopoietic cells. Overexpression of RacGAP1 has been associated with the development of bladder cancer, gastric cancer, colorectal cancer and uterine carcinosarcoma. Loss of the gene leads to the formation of multinucleated cells and inhibition of cytokinesis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Certificates of Analysis (COA)

Lot/Batch Number
211032

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Sample parameters affecting the clinical relevance of RNA biomarkers in translational breast cancer research.
Kotoula V, et al.
Virchows Archiv, 462(2), 141-154 (2013)
Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.
Wang C, et al.
Cancer Science, 109(1), 84-93 (2018)
Hiroki Imaoka et al.
Carcinogenesis, 36(3), 346-354 (2015-01-09)
Rac GTPase-activating protein (RacGAP) 1 plays a key role in controlling various cellular phenomena including cytokinesis, transformation, invasive migration and metastasis. This study investigated the function and clinical significance of RacGAP1 expression in colorectal cancer (CRC). The intrinsic functions of

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