SAB4501323
Anti-GRM5 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
GPRC1E, GRM5, MGLUR5, Metabotropic glutamate receptor 5, mGluR5
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 132 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRM5(2915)
General description
Glutamate metabotropic receptor 5 (GRM5)/metabotropic glutamate receptor subtype 5 (mGluR5) is a seven-transmembrane G-protein-coupled protein. It contains two binding sites and a structural connection to the N-methyl-D-aspartate receptor (NMDA) through a scaffold protein chain. GRM5 gene is located on human chromosome 11q14.2. Anti-GRM5 antibody detects endogenous levels of total GRM5 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human GRM5.
Immunogen Range: 21-70
Immunogen Range: 21-70
Biochem/physiol Actions
Glutamate metabotropic receptor 5 (GRM5) protein participates in glutamate signaling, supporting the action of natural stimuli, the excitability of N-methyl-D-aspartate receptor (NMDA) receptor, and abnormal synaptic plasticity in addiction. It is important for the pathophysiology and to treat eating disorders. It controls the developmental variation dependent on glutamate. It also plays a key role in adaptive synaptic plasticity, long-term potentiation, and learning. The pharmacological inhibitors of mGlu5 may have a therapeutic possibility in Bulimia nervosa (BN). Absence of mGluR5 plays a pathogenic role in autism spectrum disorder (ASD).
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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James Robert Brašić et al.
International journal of molecular sciences, 22(6) (2021-04-04)
Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) plays a role in the pathogenesis of autism spectrum disorder (ASD). Yet animal and human investigations of mGluR5 expression provide conflicting findings about the nature
Yoan Mihov et al.
Scientific reports, 10(1), 6374-6374 (2020-04-15)
Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo
Ioannis Papoulidis et al.
Molecular cytogenetics, 8, 71-71 (2015-09-22)
Interstitial deletions of the long arm of chromosome 11 are rare, and they could be assumed as non-recurrent chromosomal rearrangements due to high variability of the size and the breakpoints of the deleted region. The exact region of the deletion
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