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SAB4501435

Anti-APBB2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Amyloid β A4 precursor protein-binding family B member 2, Fe65-like protein

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 83 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

Q92870

UniProt accession no.

Q92870

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APBB2(323)

Related Categories

General description

The gene APBB2 (amyloid β precursor protein binding family B member 2) is mapped to human chromosome 4p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human APBB2.

Immunogen Range: 471-520

Biochem/physiol Actions

The gene APBB2 (amyloid β precursor protein binding family B member 2), also referred to as FE65-like 1, encodes an adaptor protein that binds to the cytoplasmic domain of β-amyloid precursor protein (βAPP) and processes it to form β-amyloid (Aβ). Over-expression of APBB2 leads to an accumulation of Aβ in senile plaques seen in patients with Alzheimer′s disease (AD). Mutations in this gene have been associated with AD.

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
3114453

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Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria.
Hsu LJ
Cellular Signalling, 20, 1303-1312 (2008)
APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.
Golanska E
Experimental Gerontology, 48, 391-394 (2013)

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