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Merck
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SAB4501527

Anti-IGFBP-3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

IBP-3, IBP3, IGF-binding protein 3, IGFBP3, Insulin-like growth factor binding protein 3 precursor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01633491
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 31 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

P17936

UniProt accession no.

P17936

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IGFBP3(3486)

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General description

Insulin-like growth factor-binding protein 3 (IGFBP3), a multifunctional protein belongs to the insulin-like growth factor binding proteins (IGFBPs) superfamily. The IGFBP3 gene is located on human chromosome 7p12. Anti-IGFBP-3 antibody detects endogenous levels of total IGFBP-3 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human IGFBP-3.

Immunogen Range: 151-200

Biochem/physiol Actions

Insulin-like growth factor-binding protein 3 (IGFBP3) can stimulate cell growth and apoptosis. It participates in DNA repair. Patients with rheumatoid arthritis show an increased level of IGFBP3 in the serum and synovial fluid. It is involved in the proliferation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs). IGFBP3 can suppress insulin-like growth factor-1 (IGF-1) signaling and modulate lung carcinogenesis and cell proliferation.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
211052

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Chia-Chia Chao et al.
Life sciences, 265, 118758-118758 (2020-11-15)
Insulin-like growth factor (IGF) signaling has been documented in several human malignancies and is thought to contribute to cellular differentiation and migration, as well as malignant progression. A major binding molecule of IGF, IGF-binding protein 3 (IGFBP-3), regulates multiple IGF
K Eggermann et al.
Annales de genetique, 42(2), 117-121 (1999-08-06)
Maternal uniparental disomy (UPD) of chromosome 7 has recently been reported in about 10% of Silver-Russell (SRS) patients. It can therefore be concluded that at least one gene on chromosome 7 is imprinted and mutations in this gene/these genes might
Roman E Ushakov et al.
Biochemical and biophysical research communications, 531(2), 133-139 (2020-08-13)
Insulin-like growth factor binding protein 3 (IGFBP3) is a multifunctional protein, able either to stimulate the cell growth or to promote apoptosis. In particular, IGFBP3 plays significant role in propagation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs)

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