SAB4501789
Anti-LTK antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Leukocyte tyrosine kinase receptor precursor, Protein tyrosine kinase-1, TYK1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 91 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LTK(4058)
General description
Anti-LTK Antibody detects endogenous levels of total LTK protein.
Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase. It is a member of the insulin receptor family. LTK is expressed in pre-B cells and brain. It is mapped to human chromosome 15q15. LTK has an ATG translational initiation codon, a secretory signal sequence, a 347 amino acid extracellular domain along with transmembrane and intracellular kinase domains.
Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase. It is a member of the insulin receptor family. LTK is expressed in pre-B cells and brain. It is mapped to human chromosome 15q15. LTK has an ATG translational initiation codon, a secretory signal sequence, a 347 amino acid extracellular domain along with transmembrane and intracellular kinase domains.
Immunogen
The antiserum was produced against synthesized peptide derived from human LTK.
Immunogen Range: 206-255
Immunogen Range: 206-255
Application
Overexpression of leukocyte tyrosine kinase (LTK) results in leukemia. It participates in cell growth and anti-apoptotic signaling. This protein acts as a cell surface receptor for an unidentified cellular growth factor.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer.
Christina F, et al.
Cancer Letters, 196(1), 65-67 (2003)
The ltk gene encodes a novel receptor?type protein tyrosine kinase.
Krolewski JJ and Dalla?Favera R
The Embo Journal, 10(10), 2911-2919 (1991)
ALK-Activating Homologous Mutations in LTK Induce Cellular Transformation.
Roll JD and Reuther GW
PLoS ONE, 7(2), 31733-31733 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4501789-100UG | 04061837188091 |