SAB4502387
Anti-PKG2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CGK 2, Type II cGMP-dependent protein kinase, cGKII
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-PKG2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 87 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRKG2(5593)
Biochem/physiol Actions
Type II cGMP-dependent protein kinase (PRKG2) is implicated in the regulation of intestinal fluid balance in humans. The encoded protein plays an essential role in proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function is associated with the development of renal cysts, intellectual disability and speech defect. In rodent and bovine models, deletion of the gene leads to dwarfism.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-PKG2 Antibody detects endogenous levels of total PKG2 protein.
Type II cGMP-dependent protein kinase (PRKG2) is encoded by the gene mapped to human chromosome 4q13.1–q21.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human PKG2.
Immunogen Range: 92-141
Immunogen Range: 92-141
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Functional Analysis of Phenotypic Behaviors of a 5-Year-Old Male with Novel 4q21 Microdeletion
Fee A, et al.
ournal of Pediatric Neuropsychology,, 1(1-4), 36-41 (2015)
Further defining the critical genes for the 4q21 microdeletion disorder
Hu X, et al.
American Journal of Medical Genetics, 173(1), 120-125 (2017)
Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2
Koltes JE, et al.
BMC Research Notes, 8(1), 177-177 (2015)
O Witczak et al.
Biochemical and biophysical research communications, 245(1), 113-119 (1998-05-16)
The type II cGMP-dependent protein kinase (cGK) plays a pivotal role in the regulation of intestinal fluid balance in man. Furthermore, mice carrying a null mutation for the gene encoding the type II cGK develop as dwarfs indicating that this
Xu Ding et al.
Journal of neuroinflammation, 17(1), 190-190 (2020-06-18)
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease. Some children with OMS also have neuroblastoma (NB). We and others have previously documented that serum IgG from children with OMS and NB induces neuronal cytolysis and activates several signaling pathways. However
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