SAB4502724
Anti-CIDEC, C-Terminal antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Cell death activator CIDE-3, Cell death-inducing DFFA-like effector protein C, FSP27, Fat-specific protein FSP27 homolog
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 26 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CIDEC(63924)
General description
CIDEC (cell death inducing DFFA (DNA fragmentation factor subunit α) like effector c) is mapped to human chromosome 3p25.3. The gene codes for FSP27 (fat-specific protein 27) also known as CIDEC. The encoded protein is localized to the lipid droplets surface. The gene is predominantly expressed in white adipose tissues and also expressed in liver and kidney.
Anti-CIDEC Antibody detects endogenous levels of total CIDEC protein. Cell death-inducing DFFA-like effector protein C (CIDEC) is localized on the surface of lipid droplets in adipocytes.
Immunogen
The antiserum was produced against synthesized peptide derived from human CIDEC.
Immunogen Range: 189-238
Immunogen Range: 189-238
Biochem/physiol Actions
CIDEC might be responsible for adipocytes differentiation. It is involved in the regulation of lipid droplet morphology and controls the lipid droplets size by inhibiting lipolysis. It is responsible for the triglycerides buildup in adipocytes. Upregulation of the gene is observed in obesity. Overexpression of the gene decreases the fatty acid oxidation (FAO) rate.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome in the context of inherited lipodystrophies.
Reinier F
Metabolism, Clinical and Experimental, 64(11), 1530-1540 (2015)
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate.
Vila-Brau A
Journal of Lipid Research, 54(3), 592-601 (2013)
Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.
Xu MJ
Gastroenterology, 149(4), 1030-1041 (2015)