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SAB4503074

Anti-VGF, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

VGF nerve growth factor inducible, neuro-endocrine specific VGF, neurosecretory protein VGF

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 67 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

O15240

UniProt accession no.

O15240

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VGF(7425)

General description

Anti-VGF Antibody detects endogenous levels of total VGF protein.
The VGF (VGF nerve growth factor inducible) gene is mapped to human chromosome 7q22.1 and codes for a neuropeptide, highly expressed in brain.

Immunogen

The antiserum was produced against synthesized peptide derived from human VGF.

Immunogen Range: 454-503

Biochem/physiol Actions

VGF (VGF nerve growth factor inducible) when induced by neurotrophins such as brain-derived neurotrophic factor, is believed to enhance neuron formation in hippocampus. The gene has an influence on a number of biological processes through its proteolytically digested peptide. Processes include metabolic homeostasis, memory, pain, circadian rhythm, regulation of arginine vasopressin secretion, neurodegeneration and neuropsychiatric disorders. Downregulation of the gene was observed in depression and human bipolar disorder. The encoded growth factor has neuroprotective action on impaired neurons in order to support cell survival.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3117031

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Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms
Behnke J, et al.
International Journal of Molecular Sciences, 18(3), 612-612 (2017)
The Neurotrophin-Inducible Gene Vgf Regulates Hippocampal Function and Behavior through a Brain-Derived Neurotrophic Factor-Dependent Mechanism
Bozdagi O, et al.
The Journal of Neuroscience, 28(39), 9857-9869 (2008)

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