SAB4503087
Anti-WASP antibody produced in rabbit
affinity isolated antibody
Synonym(s):
IMD2, WAS, Wiskott-Aldrich syndrome protein, Wiskott-Aldrich syndrome protein homolog
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 52 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... WAS(7454)
General description
Anti-WASP Antibody detects endogenous levels of total WASP protein.
WASP (Wiskott-Aldrich syndrome protein) codes for a 65 kDa protein, localized to the cytoplasm. The WASP gene is mapped to human chromosome Xp11.23.
Immunogen
The antiserum was produced against synthesized peptide derived from human WASP.
Immunogen Range: 256-305
Immunogen Range: 256-305
Biochem/physiol Actions
WASP (Wiskott-Aldrich syndrome protein) is regarded as a scaffold protein that integrates cell surface signals to actin cytoskeleton. WASP gene regulates actin polymerization, contributing to T-cell activation and migration. Neural WASP is known to regulate a variety of cellular processes including pathogen infection, vesicle trafficking, invadopodium formation and growth, and neurite extension. Mutation in this gene causes WAS, a X-linked recessive immunodeficiency disorder.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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X-Linked Syndrome of Polyendocrinopathy, Immune Dysfunction, and Diarrhea Maps to Xp11.23-Xq13.3
Bennett CL, et al.
American Journal of Human Genetics, 66(2), 461-468 (2000)
Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion
Frugtniet BA, et al.
BMC Cancer, 17(1), 224-224 (2017)
Novel WASP mutation in a patient with Wiskott-Aldrich syndrome: Case report and review of the literature.
Eghbali M, et al.
Allergologia et Immunopathologia, 44(5), 450-454 (2016)
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α
Jain N, et al.
Scientific Reports, 5, 15031-15031 (2015)
Sudha Kumari et al.
The EMBO journal, 39(5), e102783-e102783 (2020-01-03)
When migratory T cells encounter antigen-presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are critical for T-cell immunity. While the cellular processes underlying synapse formation
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