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SAB4503376

Anti-GPR174 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FKSG79, GPR174, Probable G-protein coupled receptor 174

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
3

Key Documents

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Quality Level

100

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 38 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

NCBI accession no.

Q9BXC1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GP174(84636)

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General description

G protein-coupled receptor 174 (GPR174) is a 333 amino acid protein encoded by the gene with one exon mapped to human chromosome Xq21.1. GPR174 is a member of G protein–coupled receptor 1(GPCR1) / rhodopsin-like family. The encoded protein consists of seven α -helical transmembrane domains. The protein is predominantly expressed in immune related tissues, and it is expressed at low levels in thyroid.

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR174.

Immunogen Range: 131-180

Biochem/physiol Actions

G protein-coupled receptor 174 (GPR174) plays a vital role in inducing signal transduction in immune cells. GPR174 upon lysophosphatidylserine (LysoPS) binding, enhances the production of intracellular cyclic adenosine monophosphate (cAMP) in a dose dependent manner. Mutation in GPR174 gene can be a risk factor for Graves′ disease (GD) and autoimmune addison′s disease (AAD). Upregulation of intracellular cAMP by GPR174 leads to the inhibition of immune cell proliferation. GPR174, as a LysoPS receptor, might play a crucial role in the central nervous system. Alteration in the expression of the gene results in vasovagal syncope (VVS). Overexpression of GPR174 is observed in subcutaneous metastases. Lysophosphatidylserine (LysoPS) secreted by the immune system in vivo, acts as a ligand for GPR174.

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
61312

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An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.
Chu X, et al.
Journal of medical Genetics, 50(7), 479-485 (2013)
Role of the X-linked gene GPR174 in autoimmune Addison's disease.
Napier C, et al.
The Journal of Clinical Endocrinology and Metabolism, 100(1), E187-E190 (2015)
Y Qin et al.
Pigment cell & melanoma research, 24(1), 207-218 (2010-10-01)
G-protein-coupled receptors (GPCRs) have been implicated in the tumorigenesis and metastasis of human cancers and are considered amongst the most desirable targets for drug development. Utilizing a robust quantitative PCR array, we quantified expression of 94 human GPCRs, including 75

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