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Merck
CN

SAB4503695

Anti-GASP1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

G-protein coupled receptor-associated sorting protein 1, GASP, GASP-1, GPRASP1, KIAA0443

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 156 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100

NCBI accession no.

Q5JY77

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GASP1(9737)

General description

Anti-GASP1 Antibody detects endogenous levels of total GASP1 protein.
G-protein coupled receptor-associated sorting protein 1 (GASP-1) is expressed at high level in the olfactory bulb, hippocampus, hypothalamus and some thalamic and cortical regions. It is located on human chromosome Xq22. It is also termed as WFIKKNRP or WFIKKN2. GASP-1 has a whey acidic protein domain, a follistatin/Kazal domain, an Ig domain, two tandem Kunitz domains and a netrin domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human GASP1.

Immunogen Range: 741-790

Biochem/physiol Actions

G-protein coupled receptor-associated sorting protein 1 (GASP-1) acts as a ubiquitous tumor marker. It plays an important role in the post endocytic sorting process. It is also expected to play a major role in recycling and degradation of several G-protein-coupled receptors (GPCRs).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3115957

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Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1
Martini L, et al.
Faseb Journal, 21(3), 802-811 (2007)
Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
Lee YS and Lee SJ
Proceedings of the National Academy of Sciences of the USA (2013)
Impaired striatum-dependent behavior in GASP-1-knock-out mice
Mathis C, et al.
Genes, Brain, and Behavior, 10(3), 299-308 (2011)
G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker
Zheng X, et al.
Experiments in Microbial Genetics, 93(1), 111-115 (2012)
A novel Xq22.1 deletion in a male with multiple congenital abnormalities and respiratory failure
Cao Y and Aypar U
European Journal of Medical Genetics, 59(5), 274-277 (2016)

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