Anti-phospho-eEF2 (pThr⁵⁶) antibody produced in rabbit

Eukaryotic elongation factor 2 (eEF2) is a cytoplasmic protein encoded by the gene mapped to human chromosome 19.

The antiserum was produced against synthesized peptide derived from human eEF2 around the phosphorylation site of Thr56.

Immunogen Range: 31-80

Eukaryotic elongation factor 2 (eEF2) plays a vital role in the elongation of polypeptide chain via catalyzing the translocation of the two tRNAs and the mRNA after peptidyl transfer on the 80S ribosome. eEF2 is highly expressed in various human cancers such as lung, esophageal, pancreatic, breast and prostate cancers, head and neck squamous cell carcinoma (HNSCC), glioblastoma multiforme and non-Hodgkins lymphoma (NHL). eEF2 is used as a potential marker for the diagnosis of non-small cell lung cancer (NSCLC). eEF2 activity is inhibited by the eukaryotic elongation factor-2 kinase (eEF2K), which is essential for the transmission of growth and stress signals to protein synthesis. eEF2 functions as a biochemical sensor in neuronal dendrites that links miniature synaptic events to local translational inactivation. eEF2 is also involved in nuclear deformation and aneuploidy.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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