SAB4503858
Anti-phospho-CD19 (pTyr531) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 61 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CD19(930)
General description
The gene CD19 (B-lymphocyte antigen) is located on human chromosome 16p11. The encoded protein is a transmembrane protein which is specific to B-cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human CD19 around the phosphorylation site of Tyr531.
Immunogen Range: 501-550
Immunogen Range: 501-550
Biochem/physiol Actions
CD19 (B-lymphocyte antigen) plays an important role in BCR (B cell receptor) signaling. It serves as a B cell receptor (BCR) co-receptor. In B cells, phosphorylated CD19 induces signaling of SRC-family kinase (SFK) LYN and tyrosine kinases. It also participates in B-cell selection and differentiation. In mice, overexpression of CD19 causes hyper-responsive to BCR induction, thus resulting in lupus-like autoimmune disease. Mutations in this gene can result in common variable immunodeficiency (CVID) in humans.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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An antibody-deficiency syndrome due to mutations in the CD19 gene
van Zelm MC, et al.
The New England Journal of Medicine, 354(18), 1901-1912 (2006)
CD19 controls Toll-like receptor 9 responses in human B cells
Morbach H, et al.
The Journal of Allergy and Clinical Immunology, 137(3), 889-898 (2016)
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