Merck
CN
All Photos(1)

Documents

Safety Information

SAB4700262

Sigma-Aldrich

Monoclonal Anti-CD105 antibody produced in mouse

clone MEM-229, purified immunoglobulin, buffered aqueous solution

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Anti-ENG, Anti-Endoglin
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MEM-229, monoclonal

form

buffered aqueous solution

species reactivity

human, pig

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG2a

NCBI accession no.

NM_000118.2

UniProt accession no.

P17813

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... ENG(2022)

Related Categories

General description

CD105, also known as endoglin (ENG) gene is mapped to human chromosome 9q34.11. The gene codes for a homodimeric transmembrane coreceptor containing disulfide-linked subunits of 95kDa. The encoded protein is mainly expressed on human pre-erythroblasts, macrophages, leukemic cells of the lymphoid and myeloid lineages. It is also present at higher levels on syncytiotrophoblasts of term placenta and vascular endothelial cells.
The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Immunogen

Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)

Biochem/physiol Actions

CD105/ endoglin (ENG) acts as an accessory receptor within transforming growth factor (TGF)-β signalling pathway. It is implicated in the regulation of TGF-β-dependent cellular responses. The protein expressed in endothelial cells plays a vital role in angiogenesis and tumour progression. CD105 functions as a potential target of epigenetic silencing in lung cancer. Deletion of the gene leads to hereditary hemorrhagic telangiectasia. In addition, mutations in the gene is also associated with various cardiovascular anomalies and different types of cancers.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Novel 9q34.11 gene deletions encompassing combinations of four Mendelian disease genes: STXBP1, SPTAN1, ENG, and TOR1A.
Campbell IM
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 14, 868-876 (2012)
Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer
O'Leary K
British Journal of Cancer, 113, 970-978 (2015)
Endoglin Is a Component of the Transforming Growth Factor-@ Receptor System in Human Endothelial Cells*
Cheifetz S
The Journal of Biological Chemistry, 267, 19027-19030 (1992)
CD105 (Endoglin) Is Highly Overexpressed in a Subset of Cases of Acute Myeloid Leukemias
Chakhachiro ZI
American Journal of Clinical Pathology, 140, 370-378 (2013)
Qifei Wang et al.
Molecular medicine reports, 13(6), 4636-4642 (2016-04-16)
The aim of the present study was to evaluate the different expression levels of thyroid hormone responsive (THRSP; Spot14)/S14 related, Mig12 (S14R) during bone marrow mesenchymal stem cell (BM-MSC) adipogenesis in adolescent idiopathic scoliosis (AIS) patients. MSCs were retrospectively isolated from

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service