Imprint^® ChIP-Validated Monoclonal Anti-p53 (PAb1801) antibody produced in mouse

Tumor protein p53, also called as guardian of the genome, is encoded by the gene mapped to human chromosome 17p13.1. p53 is a sequence-specific transcription factor containing transactivation domain, proline-rich domain, specific DNA-binding domain (DBD) and a tetramerization domain. In addition, it also contains a nonspecific DNA-binding domain that might be involved in DNA damage recognition.

Tumor protein p53 prevents tumor progression through transcriptional regulation of targeted genes involved in cell cycle arrest, DNA repair, apoptosis and cell senescence. Mutation in the gene leads to the development of various types of human cancers including liver fluke-associated cholangiocarcinoma (CCA). p53 also cause Li-Fraumeni syndrome (LFS) in its mutated form.

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

ChIP Validation:

View ChIP Validation Data for lot number: 032M4762

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