SAB5300387
Monoclonal Anti-RET antibody produced in mouse
clone 8D10C9, ascites fluid
Synonym(s):
RET
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
8D10C9, monoclonal
Application:
direct ELISA
western blot
western blot
Species reactivity:
human
Citations:
5
Technique(s):
direct ELISA: 1:10,000
western blot: 1:500-1:2,000
western blot: 1:500-1:2,000
Uniprot accession no.:
Product Name
Monoclonal Anti-RET antibody produced in mouse, clone 8D10C9, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
8D10C9, monoclonal
species reactivity
human
technique(s)
direct ELISA: 1:10,000
western blot: 1:500-1:2,000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RET(5979)
Biochem/physiol Actions
The RET (rearranged during transfection) is involved in signal transduction pathways related to cell proliferation and differentiation. Mutations in RET gene results in medullary thyroid carcinoma and Hirschsprung′s disease. It is involved in normal development and cancer. The isoforms of RET provides distinct protein complexes to promote signals.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The RET (rearranged during transfection) proto-oncogene is mapped to human chromosome 10q11. It has two isoforms, namely RET9 and RET51 with unique C-terminal tail sequences. RET is made of 20 exons and 21 introns.
Immunogen
Purified recombinant fragment of RET (aa896-1063) expressed in E.coli.
Mouse monoclonal antibody raised against RET
Mouse monoclonal antibody raised against RET
Physical form
Ascitic fluid containing 0.03% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Differential recruitment of E3-ubiquitin ligase complexes regulates RET isoform internalization.
Hyndman BD, et al.
Journal of Cell Science, 130(19), 3282-3296 (2017)
Associations between RET tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer.
He C, et al.
PLoS ONE, 12(11), e0187968-e0187968 (2017)
Rui-Xue Huang et al.
International journal of clinical and experimental pathology, 8(5), 5793-5797 (2015-07-21)
The purpose of the study is to investigate the relationship between rs1799939, rs1800858 and rs74799832 polymorphisms of RET with thyroid cancer (TC) susceptibility. Genotypes distribution of control groups were tested by Hardy-Weinberg equilibrium (HWE). Rs1799939, rs1800858 and rs74799832 polymorphisms of
C Tomuschat et al.
Pediatric surgery international, 31(8), 701-710 (2015-07-15)
During the past two decades several genes have been identified that control morphogenesis and differentiation of the enteric neuron system (ENS). These genes, when mutated or deleted, interfere with ENS development. RET gene is the major gene causing Hirschsprung's disease
Marjan Zarif Yeganeh et al.
Asian Pacific journal of cancer prevention : APJCP, 16(6), 2107-2117 (2015-04-01)
Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is
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