SAB5300387
Monoclonal Anti-RET antibody produced in mouse
clone 8D10C9, ascites fluid
Synonym(s):
RET
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
8D10C9, monoclonal
Application:
ELISA (d), WB
Citations:
5
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
8D10C9, monoclonal
species reactivity
human
technique(s)
direct ELISA: 1:10,000, western blot: 1:500-1:2,000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RET(5979)
General description
The RET (rearranged during transfection) proto-oncogene is mapped to human chromosome 10q11. It has two isoforms, namely RET9 and RET51 with unique C-terminal tail sequences. RET is made of 20 exons and 21 introns.
Immunogen
Purified recombinant fragment of RET (aa896-1063) expressed in E.coli.
Mouse monoclonal antibody raised against RET
Mouse monoclonal antibody raised against RET
Biochem/physiol Actions
The RET (rearranged during transfection) is involved in signal transduction pathways related to cell proliferation and differentiation. Mutations in RET gene results in medullary thyroid carcinoma and Hirschsprung′s disease. It is involved in normal development and cancer. The isoforms of RET provides distinct protein complexes to promote signals.
Physical form
Ascitic fluid containing 0.03% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Associations between RET tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer.
He C, et al.
PLoS ONE, 12(11), e0187968-e0187968 (2017)
Differential recruitment of E3-ubiquitin ligase complexes regulates RET isoform internalization.
Hyndman BD, et al.
Journal of Cell Science, 130(19), 3282-3296 (2017)
Rui-Xue Huang et al.
International journal of clinical and experimental pathology, 8(5), 5793-5797 (2015-07-21)
The purpose of the study is to investigate the relationship between rs1799939, rs1800858 and rs74799832 polymorphisms of RET with thyroid cancer (TC) susceptibility. Genotypes distribution of control groups were tested by Hardy-Weinberg equilibrium (HWE). Rs1799939, rs1800858 and rs74799832 polymorphisms of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB5300387-100UL | 04061837600593 |