SAB5500134
Anti-KI-67 antibody, Rabbit monoclonal
clone SP6, recombinant, expressed in proprietary host, tissue culture supernatant
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
SP6, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
bovine
technique(s)
immunohistochemistry: 1:200
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... MKI67(4288)
General description
Ki-67 is a nuclear protein, which is expressed in the proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.
Immunogen
Synthetic peptide from C-terminus of human Ki-67 protein.
Application
Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.
Biochem/physiol Actions
Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Ki67 labelling index: an independent predictor of progression in prostate cancer treated by radical prostatectomy.
Bubendrof L, et al.
The Journal of Pathology, 178(4), 437-441 (1996)
The Ki?67 protein: from the known and the unknown.
Scholzen T and Johannes G
Journal of Cellular Physiology, 182(3), 311-322 (2000)
Veronique L Veenstra et al.
Molecular oncology, 11(8), 1050-1064 (2017-05-10)
Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma
Janneke F Linnekamp et al.
Cancers, 13(10) (2021-06-03)
DNA hypermethylation is common in colon cancer. Previously, we have shown that methylation of WNT target genes predicts poor prognosis in stage II colon cancer. The primary objective of this study was to assess whether pre-operative treatment with decitabine can
Tal Falick Michaeli et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(52), e2212306119-e2212306119 (2022-12-20)
Injury to muscle brings about the activation of stem cells, which then generate new myocytes to replace damaged tissue. We demonstrate that this activation is accompanied by a dramatic change in the stem-cell methylation pattern that prepares them epigenetically for
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